Five reference centres (RC) were set up in 2005 for quality management and training within the programme. The directors of the RCs are obliged to head one screening unit in the region assigned to him/her. This screening unit serves as a reference screening unit for the training of other screening units and their staff.
In 2017, the five reference centres were certified as European Reference Centres for Breast Screening by the European Reference Organisation for Quality Assured Breast Screening and Diagnostic Services (EUREF). This is the highest certification provided for by EU guidelines.
In 2023 the RCs were once again subjected to a comprehensive examination and were re-certified after achieving excellent results.